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The self-association of benzethonium chloride (BZCl) in aqueous solution has been analyzed as a function of temperature. The critical micelle concentration (CMC.), the degree of counterion binding (β) and thermodynamic parameters of micellization (molar Gibbs energy, enthalpy and entropy of micellization) were determined using six experimental methods (conductometry, potentiometry, UV spectrophotometry, spectrofluorimetry, NMR and densitometry) within the temperature range 20 – 50 °C. All methods used gave very similar values for CMC. Changes in the thermodynamic parameters on micellization were determined by applying a mass action model.
From Jarmila Oremusová 1 | Zuzana Vitková 2 | Anton Vitko 3
1Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic
2Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic
3Institute of Control and Industrial Informatics, Faculty of Electrical Engineering and Informatics, Ilkovic?ova 3, 81219 Bratislava, Slovak Republic
2Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic
3Institute of Control and Industrial Informatics, Faculty of Electrical Engineering and Informatics, Ilkovic?ova 3, 81219 Bratislava, Slovak Republic
(Received 22.07.2011; revised 15.04.2012)
Appeared in Tenside Surfactants Detergents 2012/04, Page 322-329
Direct link: http://www.tsd-journal.com/TS110198
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Study of Micelle Properties and Thermodynamics of Micellization of the Benzethonium Chloride [345 KB]
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References
1 Malmstein, M.: Surfactants and Polymers in Drug Delivery, Ed. Swarbrick James, PharmaceuTech, Inc. Pinehurst, North Carolina, USA (2002) pp. 1–26.
2 Cross, J. and Singer, E. J.: Cationic Surfactants (Analytical and Biological Evaluation), Ed. Marcel Dekker, New York (1994) pp. 1–60.
3 Wong, Y. L., Curfman, C. L. and Donce, G. F.: Tetrahedron 58 (2002) 45.
4 Khan, Z. H. and Khanna, B. N.: J. Chem. Phys. 59 (1973) 3015.
5 Kalyansundaram, K. and Thomas, J. K.: J. Am. Chem. Soc. 9 (1977) 2039.
6 Turro, N. Y., Kuo, P. Z., Somasundaran, P. and Wong, K.: J. Phys. Chem. 90 (1986) 280.
7 Aguiar, J., Carpana, P., Malina-Bohver, J. A. and Carnero Ruiz, C.: J. Colloid Interface Sci. 258 (2003) 116.
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